Assuming you're using a different wheel with 4.5" backspacing, yes it will fit. You might want to get some extended bumpers to reduce the stresses it will place on the stock carrier (that thing is just pot metal, after all).
As far as weight, there have been some reports of the additional stress causing the spot welds on the rear gate to pull out over time. But there have been others who report no problems.
All I can suggest is to keep an eye on it, and plan on getting an aftermarket rear bumper and tire carrier.